Mendelian genetics of male infertility

Genetics and Male Infertility

Male are the sole cause of infertility in approximately 20% of infertile couples and are an important contributing factor in another 20-40% of couples with reproductive failure. Male infertility can result from a variety of causes. Some, like ductal obstruction and hypogonadotropic hypogonadism, can be accurately defined and effectively treated. Genetic abnormalities can cause infertility by in...

Silber GENETICS OF MALE INFERTILITY

LEARNING OBJECTIVES 1. The ART physician should understand the structure of the Y chromosome, why it harbors genes required for spermatogenesis, and why it so frequently has deletions which result in azoospermia and severe oligospermia. 2. The ART physician should understand the pitfalls in interpreting standard Y deletion testing, and be able to identify those STS markers which are robust and ...

Genetics of human male infertility.

Infertility is defined as a failure to conceive in a couple trying to reproduce for a period of two years without conception. Approximately 15 percent of couples are infertile, and among these couples, male factor infertility accounts for approximately 50 percent of causes. Male infertility is a multifactorial syndrome encompassing a wide variety of disorders. In more than half of infertile men...

Male Infertility: Genetics, Mechanism, and Therapies.

Mendelian Genetics

Much of our understanding of genetics today is taken for granted, as the use of DNA has become common in forensics and medicine. However, compared to many fields in biology, genetics is relatively young. Mendel’s “Laws” of inheritance were rediscovered in the early 1900s, and Watson and Crick described the structure of DNA only about fifty years ago (if you are interested in exploring the histo...